Unlimited Genetic Switches for Cell-Type-Specific Manipulation

Cell-Specific Cre Strains For Genetic Manipulation in Salivary Glands

The secretory acinar cells of the salivary gland are essential for saliva secretion, but are also the cell type preferentially lost following radiation treatment for head and neck cancer. The source of replacement acinar cells is currently a matter of debate. There is evidence for the presence of adult stem cells located within specific ductal regions of the salivary glands, but our laboratory ...

Layer, Column and Cell-Type Specific Genetic Manipulation in Mouse Barrel Cortex

Sensory information is processed in distributed neuronal networks connected by intricate synaptic circuits. Studies of the rodent brain can provide insight into synaptic mechanisms of sensory perception and associative learning. In particular, the mouse whisker sensorimotor system has recently begun to be investigated through combinations of imaging and electrophysiology, providing data correla...

Endophytic Fungi, Characteristics and Their Potential for Genetic Manipulation

Mucosal luminal manipulation of T cell geography switches on protective efficacy by otherwise ineffective parenteral genetic immunization.

Genetic immunization holds great promise for future vaccination against mucosal infectious diseases. However, parenteral genetic immunization is ineffective in control of mucosal intracellular infections, and the underlying mechanisms have remained unclear. By using a model of parenteral i.m. genetic immunization and pulmonary tuberculosis (TB), we have investigated the mechanisms that determin...

Cell-Type-Specific Manipulation Reveals New Specificity in the Neocortical Microcircuit.

from a neonatal mouse shows sensory hair cells (red) and olivocochlear efferent neurons lacking the protein adenomatous polyposis coli (APC, green). Input from olivocochlear efferents is necessary for the normal development of mechanotransduction in sensory hair cells. The loss of APC neonatally in these efferents leads to reduced hearing and abnormal afferent synapse development. For more info...